Harnessing Avidity: Quantifying the Entropic and Energetic Effects of Linker Length and Rigidity for Multivalent Binding of Antibodies to HIV-1

IgG antibodies increase their apparent affinities by using both of their Fabs to simultaneously attach to antigens. HIV-1 foils this strategy by having few, and highly separated, Envelope (Env) spike targets for antibodies, forcing most IgGs to bind monovalently. Here, we develop a statistical mecha...

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Detalles Bibliográficos
Autores principales: Einav, Tal, Yazdi, Shahrzad, Coey, Aaron, Bjorkman, Pamela J., Phillips, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892280/
https://www.ncbi.nlm.nih.gov/pubmed/31668801
http://dx.doi.org/10.1016/j.cels.2019.09.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892280/
https://www.ncbi.nlm.nih.gov/pubmed/31668801
http://dx.doi.org/10.1016/j.cels.2019.09.007

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