Pro-renin receptor suppresses mitochondrial biogenesis and function via AMPK/SIRT-1/ PGC-1α pathway in diabetic kidney

Abnormal mitochondrial biogenesis and function has been linked to multiple diseases including diabetes. Recently, we demonstrated the role of renal (Pro)renin receptor (PRR) in the dysregulation of mitochondria. We hypothesized that PRR contributes to the reduction of mitochondrial biogenesis and fu...

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Detalles Bibliográficos
Autores principales: Akhtar, Safia, Siragy, Helmy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892478/
https://www.ncbi.nlm.nih.gov/pubmed/31800607
http://dx.doi.org/10.1371/journal.pone.0225728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892478/
https://www.ncbi.nlm.nih.gov/pubmed/31800607
http://dx.doi.org/10.1371/journal.pone.0225728

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