Cargando…

Glioblastoma Model Using Human Cerebral Organoids

We have developed a cancer model of gliomas in human cerebral organoids that allows direct observation of tumor initiation as well as continuous microscopic observations. We used CRISPR/Cas9 technology to target an HRas(G12V)-IRES-tdTomato construct by homologous recombination into the TP53 locus. R...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ogawa, Junko, Pao, Gerald M., Shokhirev, Maxim N., Verma, Inder M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892608/ https://www.ncbi.nlm.nih.gov/pubmed/29694897 http://dx.doi.org/10.1016/j.celrep.2018.03.105

Ejemplares similares

Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration
por: Fedorova, Veronika, et al.
Publicado: (2023)

Cerebral organoids: emerging ex vivo humanoid models of glioblastoma
por: Papaioannou, Michail-Dimitrios, et al.
Publicado: (2020)

Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics
por: Krieger, Teresa G, et al.
Publicado: (2020)

Cerebral organoids model human brain development and microcephaly
por: Lancaster, Madeline A., et al.
Publicado: (2013)

Modeling human brain development with cerebral organoids
por: Muzio, Luca, et al.
Publicado: (2013)

SARS-CoV2 entry factors are expressed in primary human glioblastoma and recapitulated in cerebral organoid models
por: Suarez-Meade, Paola, et al.
Publicado: (2023)

Modeling the human aging transcriptome across tissues, health status, and sex
por: Shokhirev, Maxim N., et al.
Publicado: (2020)

Modelling Toxoplasma gondii infection in human cerebral organoids
por: Seo, Hyang-Hee, et al.
Publicado: (2020)

Modeling Traumatic Brain Injury in Human Cerebral Organoids
por: Ramirez, Santiago, et al.
Publicado: (2021)

Cerebral Malaria Model Applying Human Brain Organoids
por: Silva-Pedrosa, Rita, et al.
Publicado: (2023)

Lineage recording in human cerebral organoids
por: He, Zhisong, et al.
Publicado: (2021)

Organoid Models of Glioblastoma and Their Role in Drug Discovery
por: Rybin, Matthew J., et al.
Publicado: (2021)

Nanotherapeutic Modulation of Human Neural Cells and Glioblastoma in Organoids and Monocultures
por: Zhang, Issan, et al.
Publicado: (2020)

Multiscale 3D phenotyping of human cerebral organoids
por: Albanese, Alexandre, et al.
Publicado: (2020)

Analysis of Synapses in Cerebral Organoids
por: Yakoub, Abraam M., et al.
Publicado: (2019)

Development and Characterization of Human Cerebral Organoids: An Optimized Protocol
por: Yakoub, Abraam M., et al.
Publicado: (2018)

Derivation of Functional Human Astrocytes from Cerebral Organoids
por: Dezonne, Rômulo Sperduto, et al.
Publicado: (2017)

Cerebral Organoids as an Experimental Platform for Human Neurogenomics
por: Nowakowski, Tomasz J., et al.
Publicado: (2022)

Human cerebral organoids: the ethical stance of scientists
por: Lavazza, Andrea, et al.
Publicado: (2023)

New approaches to model glioblastoma in vitro using brain organoids: implications for precision oncology
por: Gomez, Guillermo A., et al.
Publicado: (2019)

Human Blood Vessel Organoids Penetrate Human Cerebral Organoids and Form a Vessel-Like System
por: Ahn, Yujin, et al.
Publicado: (2021)

Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
por: Urbaniak, Alicja, et al.
Publicado: (2022)

Organoid Models of Glioblastoma to Study Brain Tumor Stem Cells
por: Azzarelli, Roberta
Publicado: (2020)

Generation of Human Blood Vessel and Vascularized Cerebral Organoids
por: Sun, Xin-Yao, et al.
Publicado: (2023)

The moral status of cerebral organoids
por: Hostiuc, Sorin, et al.
Publicado: (2019)

Using our mini-brains: cerebral organoids as an improved cellular model for human prion disease
por: Groveman, Bradley R., et al.
Publicado: (2019)

Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain
por: Depla, Josse A., et al.
Publicado: (2020)

Three-dimensional model of glioblastoma by co-culturing tumor stem cells with human brain organoids
por: Azzarelli, Roberta, et al.
Publicado: (2021)

Cerebral organoids as a new model for prion disease
por: Groveman, Bradley R., et al.
Publicado: (2021)

Glial cell diversity and methamphetamine-induced neuroinflammation in human cerebral organoids
por: Dang, Jason, et al.
Publicado: (2020)

Human cerebral organoids as a therapeutic drug screening model for Creutzfeldt–Jakob disease
por: Groveman, Bradley R., et al.
Publicado: (2021)

Deficiency of N-glycanase 1 perturbs neurogenesis and cerebral development modeled by human organoids
por: Lin, Victor J. T., et al.
Publicado: (2022)

Development of glioblastoma organoids and their applications in personalized therapy
por: Xu, Can, et al.
Publicado: (2023)

Transcriptomic Profiling of Tetrodotoxin-Induced Neurotoxicity in Human Cerebral Organoids
por: Liu, Zhanbiao, et al.
Publicado: (2023)

Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol
por: Glasauer, Stella M.K., et al.
Publicado: (2022)

Human cerebral organoids and consciousness: a double-edged sword
por: Lavazza, Andrea
Publicado: (2020)

Human cerebral organoids as a new legal and ethical challenge(†)
por: Lavazza, Andrea, et al.
Publicado: (2020)

Modeling alcohol-induced neurotoxicity using human induced pluripotent stem cell-derived three-dimensional cerebral organoids
por: Arzua, Thiago, et al.
Publicado: (2020)

Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids
por: Gumbs, Stephanie B. H., et al.
Publicado: (2022)

Genetically engineered cerebral organoids model brain tumour formation
por: Bian, Shan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_r2he98tmgobqv7h0h280436ve0