eIF2α signaling regulates autophagy of osteoblasts and the development of osteoclasts in OVX mice

Bone loss in postmenopausal osteoporosis is induced chiefly by an imbalance of bone-forming osteoblasts and bone-resorbing osteoclasts. Salubrinal is a synthetic compound that inhibits de-phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α). Phosphorylation of eIF2α alleviates...

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Detalles Bibliográficos
Autores principales: Li, Jie, Li, Xinle, Liu, Daquan, Hamamura, Kazunori, Wan, Qiaoqiao, Na, Sungsoo, Yokota, Hiroki, Zhang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892793/
https://www.ncbi.nlm.nih.gov/pubmed/31801950
http://dx.doi.org/10.1038/s41419-019-2159-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892793/
https://www.ncbi.nlm.nih.gov/pubmed/31801950
http://dx.doi.org/10.1038/s41419-019-2159-z

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