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eIF2α signaling regulates autophagy of osteoblasts and the development of osteoclasts in OVX mice

Bone loss in postmenopausal osteoporosis is induced chiefly by an imbalance of bone-forming osteoblasts and bone-resorbing osteoclasts. Salubrinal is a synthetic compound that inhibits de-phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α). Phosphorylation of eIF2α alleviates...

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Detalles Bibliográficos
Autores principales:	Li, Jie, Li, Xinle, Liu, Daquan, Hamamura, Kazunori, Wan, Qiaoqiao, Na, Sungsoo, Yokota, Hiroki, Zhang, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892793/ https://www.ncbi.nlm.nih.gov/pubmed/31801950 http://dx.doi.org/10.1038/s41419-019-2159-z

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