CD40 induces renal cell carcinoma-specific differential regulation of TRAF proteins, ASK1 activation and JNK/p38-mediated, ROS-dependent mitochondrial apoptosis

A unique feature of CD40 among the TNF receptor (TNFR) superfamily is its exquisitely contextual effects, as originally demonstrated in normal and malignant B-lymphocytes. We studied renal cell carcinoma (RCC) in comparison to normal (human renal proximal tubule) cells, as a model to better understa...

Descripción completa

Detalles Bibliográficos
Autores principales: Ibraheem, Khalidah, Yhmed, Albashir M. A., Qayyum, Tahir, Bryan, Nicolas P., Georgopoulos, Nikolaos T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892818/
https://www.ncbi.nlm.nih.gov/pubmed/31815003
http://dx.doi.org/10.1038/s41420-019-0229-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892818/
https://www.ncbi.nlm.nih.gov/pubmed/31815003
http://dx.doi.org/10.1038/s41420-019-0229-8

Ejemplares similares