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CD40 induces renal cell carcinoma-specific differential regulation of TRAF proteins, ASK1 activation and JNK/p38-mediated, ROS-dependent mitochondrial apoptosis

A unique feature of CD40 among the TNF receptor (TNFR) superfamily is its exquisitely contextual effects, as originally demonstrated in normal and malignant B-lymphocytes. We studied renal cell carcinoma (RCC) in comparison to normal (human renal proximal tubule) cells, as a model to better understa...

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Detalles Bibliográficos
Autores principales:	Ibraheem, Khalidah, Yhmed, Albashir M. A., Qayyum, Tahir, Bryan, Nicolas P., Georgopoulos, Nikolaos T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892818/ https://www.ncbi.nlm.nih.gov/pubmed/31815003 http://dx.doi.org/10.1038/s41420-019-0229-8

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