Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys

CRISPR-Cas9 is a widely-used genome editing tool, but its off-target effect and on-target complex mutations remain a concern, especially in view of future clinical applications. Non-human primates (NHPs) share close genetic and physiological similarities with humans, making them an ideal preclinical...

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Detalles Bibliográficos
Autores principales: Luo, Xin, He, Yaoxi, Zhang, Chao, He, Xiechao, Yan, Lanzhen, Li, Min, Hu, Ting, Hu, Yan, Jiang, Jin, Meng, Xiaoyu, Ji, Weizhi, Zhao, Xudong, Zheng, Ping, Xu, Shuhua, Su, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892871/
https://www.ncbi.nlm.nih.gov/pubmed/31797925
http://dx.doi.org/10.1038/s41467-019-13481-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892871/
https://www.ncbi.nlm.nih.gov/pubmed/31797925
http://dx.doi.org/10.1038/s41467-019-13481-y

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