Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation

Atherosclerosis is the major cause of ischemic coronary heart diseases and characterized by the infiltration of cholesterol-accumulating macrophages in the vascular wall. Although sphingolipids are implicated in atherosclerosis as both membrane components and lipid mediators, the precise role of sph...

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Detalles Bibliográficos
Autores principales: Ishimaru, Kazuhiro, Yoshioka, Kazuaki, Kano, Kuniyuki, Kurano, Makoto, Saigusa, Daisuke, Aoki, Junken, Yatomi, Yutaka, Takuwa, Noriko, Okamoto, Yasuo, Proia, Richard L., Takuwa, Yoh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892873/
https://www.ncbi.nlm.nih.gov/pubmed/31797978
http://dx.doi.org/10.1038/s41598-019-54877-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892873/
https://www.ncbi.nlm.nih.gov/pubmed/31797978
http://dx.doi.org/10.1038/s41598-019-54877-6

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