Comprehensive Scanning Mutagenesis of Human Retrotransposon LINE-1 Identifies Motifs Essential for Function

Long Interspersed Nuclear Element-1 (LINE-1, L1) is the only autonomous active transposable element in the human genome. The L1-encoded proteins ORF1p and ORF2p enable the element to jump from one locus to another via a “copy-and-paste” mechanism. ORF1p is an RNA-binding protein, and ORF2p has endon...

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Detalles Bibliográficos
Autores principales: Adney, Emily M., Ochmann, Matthias T., Sil, Srinjoy, Truong, David M., Mita, Paolo, Wang, Xuya, Kahler, David J., Fenyö, David, Holt, Liam J., Boeke, Jef D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2019
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893370/
https://www.ncbi.nlm.nih.gov/pubmed/31666291
http://dx.doi.org/10.1534/genetics.119.302601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893370/
https://www.ncbi.nlm.nih.gov/pubmed/31666291
http://dx.doi.org/10.1534/genetics.119.302601

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