Pleiotropic Effects of Modified Citrus Pectin

Modified citrus pectin (MCP) has a low-molecular-weight degree of esterification to allow absorption from the small intestinal epithelium into the circulation. MCP produces pleiotropic effects, including but not limited to its antagonism of galectin-3, which have shown benefit in preclinical and cli...

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Detalles Bibliográficos
Autores principales: Eliaz, Isaac, Raz, Avraham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893732/
https://www.ncbi.nlm.nih.gov/pubmed/31683865
http://dx.doi.org/10.3390/nu11112619
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author Eliaz, Isaac
Raz, Avraham
author_facet Eliaz, Isaac
Raz, Avraham
author_sort Eliaz, Isaac
collection PubMed
description Modified citrus pectin (MCP) has a low-molecular-weight degree of esterification to allow absorption from the small intestinal epithelium into the circulation. MCP produces pleiotropic effects, including but not limited to its antagonism of galectin-3, which have shown benefit in preclinical and clinical models. Regarding cancer, MCP modulates several rate-limiting steps of the metastatic cascade. MCP can also affect cancer cell resistance to chemotherapy. Regarding fibrotic diseases, MCP modulates many of the steps involved in the pathogenesis of aortic stenosis. MCP also reduces fibrosis to the kidney, liver, and adipose tissue. Other benefits of MCP include detoxification and improved immune function. This review summarizes the pleiotropic effects of MCP.
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spelling pubmed-68937322019-12-23 Pleiotropic Effects of Modified Citrus Pectin Eliaz, Isaac Raz, Avraham Nutrients Review Modified citrus pectin (MCP) has a low-molecular-weight degree of esterification to allow absorption from the small intestinal epithelium into the circulation. MCP produces pleiotropic effects, including but not limited to its antagonism of galectin-3, which have shown benefit in preclinical and clinical models. Regarding cancer, MCP modulates several rate-limiting steps of the metastatic cascade. MCP can also affect cancer cell resistance to chemotherapy. Regarding fibrotic diseases, MCP modulates many of the steps involved in the pathogenesis of aortic stenosis. MCP also reduces fibrosis to the kidney, liver, and adipose tissue. Other benefits of MCP include detoxification and improved immune function. This review summarizes the pleiotropic effects of MCP. MDPI 2019-11-01 /pmc/articles/PMC6893732/ /pubmed/31683865 http://dx.doi.org/10.3390/nu11112619 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Eliaz, Isaac
Raz, Avraham
Pleiotropic Effects of Modified Citrus Pectin
title Pleiotropic Effects of Modified Citrus Pectin
title_full Pleiotropic Effects of Modified Citrus Pectin
title_fullStr Pleiotropic Effects of Modified Citrus Pectin
title_full_unstemmed Pleiotropic Effects of Modified Citrus Pectin
title_short Pleiotropic Effects of Modified Citrus Pectin
title_sort pleiotropic effects of modified citrus pectin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893732/
https://www.ncbi.nlm.nih.gov/pubmed/31683865
http://dx.doi.org/10.3390/nu11112619
work_keys_str_mv AT eliazisaac pleiotropiceffectsofmodifiedcitruspectin
AT razavraham pleiotropiceffectsofmodifiedcitruspectin

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