Cargando…

Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon

The Zika virus (ZIKV) is a member of the Flaviviridae family and an important human pathogen. Most pathogenic viruses encode proteins that interfere with the activation of host innate immune responses. Like other flaviviruses, ZIKV interferes with the expression of interferon (IFN) genes and inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lundberg, Rickard, Melén, Krister, Westenius, Veera, Jiang, Miao, Österlund, Pamela, Khan, Hira, Vapalahti, Olli, Julkunen, Ilkka, Kakkola, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893776/ https://www.ncbi.nlm.nih.gov/pubmed/31690057 http://dx.doi.org/10.3390/v11111024

Ejemplares similares

Asian and African lineage Zika viruses show differential replication and innate immune responses in human dendritic cells and macrophages
por: Österlund, Pamela, et al.
Publicado: (2019)

Filovirus VP24 Proteins Differentially Regulate RIG-I and MDA5-Dependent Type I and III Interferon Promoter Activation
por: He, Felix B., et al.
Publicado: (2022)

Highly Pathogenic H5N1 Influenza A Virus Spreads Efficiently in Human Primary Monocyte-Derived Macrophages and Dendritic Cells
por: Westenius, Veera, et al.
Publicado: (2018)

Mutations within the conserved NS1 nuclear export signal lead to inhibition of influenza A virus replication
por: Tynell, Janne, et al.
Publicado: (2014)

SARS-CoV-2 Isolates Show Impaired Replication in Human Immune Cells but Differential Ability to Replicate and Induce Innate Immunity in Lung Epithelial Cells
por: Jiang, Miao, et al.
Publicado: (2021)

Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection
por: Sillanpää, Maarit, et al.
Publicado: (2009)

Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression
por: Kaukinen, Pasi, et al.
Publicado: (2006)

Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin
por: Melén, Krister, et al.
Publicado: (2012)

Middle East respiratory syndrome coronavirus (MERS-CoV) shows poor replication and weak induction of antiviral responses in human monocyte-derived macrophages and dendritic cells
por: Tynell, J., et al.
Publicado: (2015)

A Combination of N and S Antigens With IgA and IgG Measurement Strengthens the Accuracy of SARS-CoV-2 Serodiagnostics
por: Jalkanen, Pinja, et al.
Publicado: (2021)

NS5 Conservative Site Is Required for Zika Virus to Restrict the RIG-I Signaling
por: Li, Aixin, et al.
Publicado: (2020)

Novel Avian Influenza A (H7N9) Virus Induces Impaired Interferon Responses in Human Dendritic Cells
por: Arilahti, Veera, et al.
Publicado: (2014)

Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants
por: Belik, Milja, et al.
Publicado: (2022)

COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants
por: Jalkanen, Pinja, et al.
Publicado: (2021)

Nuclear Translocation of Crk Adaptor Proteins by the Influenza A Virus NS1 Protein
por: Ylösmäki, Leena, et al.
Publicado: (2016)

Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling
por: Ibsen, Mikkel Søes, et al.
Publicado: (2015)

Blood MxA protein as a marker for respiratory virus infections in young children
por: Toivonen, Laura, et al.
Publicado: (2015)

Persistent T cell-mediated immune responses against Omicron variants after the third COVID-19 mRNA vaccine dose
por: Belik, Milja, et al.
Publicado: (2023)

Hydroxychloroquine Inhibits Zika Virus NS2B-NS3 Protease
por: Kumar, Ankur, et al.
Publicado: (2018)

Infection with a Brazilian isolate of Zika virus generates RIG‐I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling
por: Hertzog, Jonny, et al.
Publicado: (2018)

SARS-CoV-2 variants Alpha, Beta, Delta and Omicron show a slower host cell interferon response compared to an early pandemic variant
por: Laine, Larissa, et al.
Publicado: (2022)

Measurement of $\epsilon'/\epsilon$
por: Lubrano, Pasquale
Publicado: (1999)

Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling
por: Ban, Junsu, et al.
Publicado: (2018)

Dengue in Travelers: Kinetics of Viremia and NS1 Antigenemia and Their Associations with Clinical Parameters
por: Erra, Elina O., et al.
Publicado: (2013)

No evidence of autoimmunity to human OX(1) or OX(2) orexin receptors in Pandemrix-vaccinated narcoleptic children
por: Melén, Krister, et al.
Publicado: (2020)

Gluino penguins and epsilon'/epsilon
por: Gérard, J M, et al.
Publicado: (1984)

New $\epsilon{'}/\epsilon$ results
por: Biino, C
Publicado: (2001)

Influenza C virus NS1 protein counteracts RIG-I-mediated IFN signalling
por: Pachler, Karin, et al.
Publicado: (2011)

Interferon Epsilon Signaling Confers Attenuated Zika Replication in Human Vaginal Epithelial Cells
por: Mungin, James W., et al.
Publicado: (2022)

Structure of NS3 helicase from Zika virus
por: Jain, Rinku, et al.
Publicado: (2016)

Structures of NS5 Methyltransferase from Zika Virus
por: Coloma, Javier, et al.
Publicado: (2016)

Zika Virus Targeting by Screening Inhibitors against NS2B/NS3 Protease
por: Choudhry, Hani, et al.
Publicado: (2019)

Development of NS2B-NS3 protease inhibitor that impairs Zika virus replication()
por: Lin, Wen-Wei, et al.
Publicado: (2023)

Infectious viruses from transfected SARS-CoV-2 genomic RNA
por: Väisänen, Elina, et al.
Publicado: (2023)

Serological Array-in-Well Multiplex Assay Reveals a High Rate of Respiratory Virus Infections and Reinfections in Young Children
por: Kazakova, Anna, et al.
Publicado: (2019)

IKK Epsilon Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Inhibiting Inflammation, Oxidative Stress, and Apoptosis
por: Chai, Hao, et al.
Publicado: (2020)

$\epsilon'$/$\epsilon$: three years later
por: Ciuchini, Marco
Publicado: (1997)

The NA31 $\epsilon'\epsilon$ measurement
por: Nappi, A, et al.
Publicado: (1990)

Review of epsilon'/epsilon measurements and their problems
por: Wahl, H
Publicado: (1986)

$\epsilon '/\epsilon$ by the NA48 experiment
por: Sozzi, M
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_hrl6p1vtkeg9lvb3thu6satk71