5-(Hydroxyphenyl)-γ-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan-3-ols, Is Able to Reach the Brain: Evidence from Different in Silico, In Vitro and In Vivo Experimental Models

Phenolic compounds have been recognized as promising compounds for the prevention of chronic diseases, including neurodegenerative ones. However, phenolics like flavan-3-ols (F3O) are poorly absorbed along the gastrointestinal tract and structurally rearranged by gut microbiota, yielding smaller and...

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Detalles Bibliográficos
Autores principales: Angelino, Donato, Carregosa, Diogo, Domenech-Coca, Cristina, Savi, Monia, Figueira, Inês, Brindani, Nicoletta, Jang, Saebyeol, Lakshman, Sukla, Molokin, Aleksey, Urban, Joseph F., Davis, Cindy D., Brito, Maria Alexandra, Kim, Kwang Sik, Brighenti, Furio, Curti, Claudio, Bladé, Cinta, del Bas, Josep M., Stilli, Donatella, Solano-Aguilar, Gloria I., dos Santos, Claudia Nunes, del Rio, Daniele, Mena, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893823/
https://www.ncbi.nlm.nih.gov/pubmed/31694297
http://dx.doi.org/10.3390/nu11112678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893823/
https://www.ncbi.nlm.nih.gov/pubmed/31694297
http://dx.doi.org/10.3390/nu11112678

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