Cargando…

Elevated Level of PKMζ Underlies the Excessive Anxiety in an Autism Model

Anxiety affects the life quality of a significant percentage of autism patients. To understand the possible biological basis of this high anxiety level, we used a valproic acid (VPA) model of autism. Anxiety level is significantly higher in VPA-injected mice, at both P35 and P70. In addition, protei...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Xiaoli, Zheng, Rui, Ma, Xiaoyan, Gong, Zhiting, Xia, Dan, Zhou, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893886/ https://www.ncbi.nlm.nih.gov/pubmed/31849605 http://dx.doi.org/10.3389/fnmol.2019.00291

Ejemplares similares

Involvement of PKMζ in Stress Response and Depression
por: Liu, Jianfeng
Publicado: (2022)

On the Temporary Nature of Disruption of Fear-Potentiated Startle Following PKMζ Inhibition in the Amygdale
por: Nader, Karim
Publicado: (2011)

Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice
por: Tsokas, Panayiotis, et al.
Publicado: (2016)

PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain
por: Laferrière, Andre, et al.
Publicado: (2011)

Memory maintenance by PKMζ — an evolutionary perspective
por: Sacktor, Todd Charlton
Publicado: (2012)

Erasing Sensorimotor Memories via PKMζ Inhibition
por: von Kraus, Lee Michael, et al.
Publicado: (2010)

ZIPping to pain relief: the role (or not) of PKMζ in chronic pain
por: Price, Theodore J, et al.
Publicado: (2013)

Epigenetic modification of PKMζ rescues aging-related cognitive impairment
por: Chen, Chen, et al.
Publicado: (2016)

Repeated recall and PKMζ maintain fear memories in juvenile rats
por: Oliver, Chicora F., et al.
Publicado: (2016)

Specific involvement of atypical PKCζ/PKMζ in spinal persistent nociceptive processing following peripheral inflammation in rat
por: Marchand, Fabien, et al.
Publicado: (2011)

PKMζ Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories
por: Serrano, Peter, et al.
Publicado: (2008)

Temporary disruption of fear potentiated startle following PKMζ inhibition in the amygdala
por: Parsons, Ryan G., et al.
Publicado: (2011)

PKCζ and PKMζ are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity
por: Hartsink-Segers, S A, et al.
Publicado: (2015)

Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors
por: Braren, Stephen H., et al.
Publicado: (2014)

BDNF Facilitates L-LTP Maintenance in the Absence of Protein Synthesis through PKMζ
por: Mei, Fan, et al.
Publicado: (2011)

PKMζ Differentially Utilized between Sexes for Remote Long-Term Spatial Memory
por: Sebastian, Veronica, et al.
Publicado: (2013)

Environmental Enrichment Increases Glucocorticoid Receptors and Decreases GluA2 and Protein Kinase M Zeta (PKMζ) Trafficking During Chronic Stress: A Protective Mechanism?
por: Zanca, Roseanna M., et al.
Publicado: (2015)

Persistent Increases of PKMζ in Sensorimotor Cortex Maintain Procedural Long-Term Memory Storage
por: Gao, Peng Penny, et al.
Publicado: (2018)

What does LTP tell us about the roles of CaMKII and PKMζ in memory?
por: Sacktor, Todd Charlton, et al.
Publicado: (2018)

Role of prelimbic cortex PKC and PKMζ in fear memory reconsolidation and persistence following reactivation
por: da Silva, Thiago Rodrigues, et al.
Publicado: (2020)

Consistent sex-dependent effects of PKMζ gene ablation and pharmacological inhibition on the maintenance of referred pain
por: Nasir, Hibatulnaseer, et al.
Publicado: (2016)

Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors
por: Yu, Nam-Kyung, et al.
Publicado: (2017)

Transcription-independent expression of PKMζ in the anterior cingulate cortex contributes to chronically maintained neuropathic pain
por: Ko, Hyoung-Gon, et al.
Publicado: (2018)

Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury
por: Han, Jeongsoo, et al.
Publicado: (2015)

PKMζ Inhibition Reverses Learning-Induced Increases in Hippocampal Synaptic Strength and Memory during Trace Eyeblink Conditioning
por: Madroñal, Noelia, et al.
Publicado: (2010)

Lifelong reductions of PKMζ in ventral hippocampus of nonhuman primates exposed to early-life adversity due to unpredictable maternal care
por: Fulton, Sasha L., et al.
Publicado: (2021)

PKMζ knockdown disrupts post-ischemic long-term potentiation via inhibiting postsynaptic expression of aminomethyl phosphonic acid receptors
por: Cheng, Nan, et al.
Publicado: (2015)

Homolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix
por: Balaban, Pavel M., et al.
Publicado: (2015)

PKM2 and cancer: The function of PKM2 beyond glycolysis
por: DONG, GAOCHAO, et al.
Publicado: (2016)

Diabetes and PKM2 affect prognosis in patients with intrahepatic cholangiocarcinoma
por: Fu, Kui, et al.
Publicado: (2020)

Altered Relationship Between Parvalbumin and Perineuronal Nets in an Autism Model
por: Xia, Dan, et al.
Publicado: (2021)

Contextual fear memory modulates PSD95 phosphorylation, AMPAr subunits, PKMζ and PI3K differentially between adult and juvenile rats
por: Zanca, Roseanna M., et al.
Publicado: (2018)

Sensory, Emotional and Cognitive Contributions to Anxiety in Autism Spectrum Disorders
por: South, Mikle, et al.
Publicado: (2017)

Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure
por: Bohnsack, John Peyton, et al.
Publicado: (2022)

Elevated Plasma Levels of Drebrin in Glaucoma Patients With Neurodegeneration
por: Gan, Yi-Jing, et al.
Publicado: (2019)

PKM2 in carcinogenesis and oncotherapy
por: He, Xia, et al.
Publicado: (2017)

Distributed circuits underlying anxiety
por: Adhikari, Avishek
Publicado: (2014)

Striatum Shape Hypertrophy in Early Stage Parkinson’s Disease With Excessive Daytime Sleepiness
por: Gong, Liang, et al.
Publicado: (2020)

Disrupted Amygdala Connectivity Is Associated With Elevated Anxiety in Sensorineural Hearing Loss
por: Tang, Tian-Yu, et al.
Publicado: (2020)

Upstream Open Reading Frames Located in the Leader of Protein Kinase Mζ mRNA Regulate Its Translation
por: Bal, Natalia V., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_sko0v2jbgdeceqjjrmj6nq0lev