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RT(2) PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease
Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease that has been linked to defective DNA repair. Many familial ALS patients harbor autosomal dominant mutations in the gene encoding the RNA/DNA binding protein ‘fused in sarcoma’ (FUS) commonly inducing its cytoplasmic mislocal...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894127/ https://www.ncbi.nlm.nih.gov/pubmed/31801573 http://dx.doi.org/10.1186/s13041-019-0526-4 |