RT(2) PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease

Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease that has been linked to defective DNA repair. Many familial ALS patients harbor autosomal dominant mutations in the gene encoding the RNA/DNA binding protein ‘fused in sarcoma’ (FUS) commonly inducing its cytoplasmic mislocal...

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Detalles Bibliográficos
Autores principales: Wang, Haibo, Rangaswamy, Suganya, Kodavati, Manohar, Mitra, Joy, Guo, Wenting, Guerrero, Erika N., Van Den Bosch, Ludo, Hegde, Muralidhar L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Micro Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894127/
https://www.ncbi.nlm.nih.gov/pubmed/31801573
http://dx.doi.org/10.1186/s13041-019-0526-4

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