Improving selectivity of DNA–RNA binding zinc finger using directed evolution

OBJECTIVE: Type C2H2 zinc fingers bind a variety of substrates, specific sequences in the double-stranded DNA counting among them. Engineering efforts led to the discovery of a set of general rules that enable obtaining zinc fingers modules that bind to almost any given sequence. The objective of th...

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Detalles Bibliográficos
Autor principal: Sulej, Agata A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894256/
https://www.ncbi.nlm.nih.gov/pubmed/31801592
http://dx.doi.org/10.1186/s13104-019-4833-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894256/
https://www.ncbi.nlm.nih.gov/pubmed/31801592
http://dx.doi.org/10.1186/s13104-019-4833-8

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