Cargando…

Adult human cardiac stem cell supplementation effectively increases contractile function and maturation in human engineered cardiac tissues

BACKGROUND: Delivery of stem cells to the failing heart is a promising therapeutic strategy. However, the improvement in cardiac function in animal studies has not fully translated to humans. To help bridge the gap between species, we investigated the effects of adult human cardiac stem cells (hCSCs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Murphy, Jack F., Mayourian, Joshua, Stillitano, Francesca, Munawar, Sadek, Broughton, Kathleen M., Agullo-Pascual, Esperanza, Sussman, Mark A., Hajjar, Roger J., Costa, Kevin D., Turnbull, Irene C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894319/ https://www.ncbi.nlm.nih.gov/pubmed/31801634 http://dx.doi.org/10.1186/s13287-019-1486-4

Ejemplares similares

3444 Development of human engineered cardiac tissue (hECT)-based screening assay to explore cardiac contractile properties in response to pharmacological challenge with proarrhythmic drugs
por: Stillitano, Francesca, et al.
Publicado: (2019)

2525 Development of human cell-based screening assays to detect subject-specific drug-response variability
por: Stillitano, Francesca, et al.
Publicado: (2018)

Cardiac Tissue Engineering: Inclusion of Non-cardiomyocytes for Enhanced Features
por: Munawar, Sadek, et al.
Publicado: (2021)

In silico Cell Therapy Model Restores Failing Human Myocyte Electrophysiology and Calcium Cycling in Fibrotic Myocardium
por: Phillips, Katherine G., et al.
Publicado: (2022)

In vitro effect of leptin on human cardiac contractility
por: Chaban, Ryan, et al.
Publicado: (2019)

Human CardioChimeras: Creation of a Novel “Next‐Generation” Cardiac Cell
por: Firouzi, Fareheh, et al.
Publicado: (2020)

Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues
por: Wong, Andy On-Tik, et al.
Publicado: (2021)

Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues
por: Wong, Andy O.-T., et al.
Publicado: (2021)

Regulation of Cardiac Muscle Contractility
por: Katz, Arnold M.
Publicado: (1967)

3213 Unraveling the role of Phospholamban (PLN) in humans via the characterization of Induced Pluripotent Stem Cell (iPSC) Cardiomyocytes (CM) derived from carriers of a lethal PLN mutation
por: Trivieri, Maria Giovanna, et al.
Publicado: (2019)

Inhibition of miR-25 Improves Cardiac Contractility in the Failing Heart
por: Wahlquist, Christine, et al.
Publicado: (2014)

The Ionic Dependence of Cardiac Excitability and Contractility
por: Brady, Allan J., et al.
Publicado: (1966)

Cardiac contractility modulation therapy: Are there superresponders?
por: Al-Ghamdi, Bandar, et al.
Publicado: (2017)

Rianú: Multi-tissue tracking software for increased throughput of engineered cardiac tissue screening
por: Murphy, Jack F., et al.
Publicado: (2023)

TBX20 Improves Contractility and Mitochondrial Function During Direct Human Cardiac Reprogramming
por: Tang, Yawen, et al.
Publicado: (2022)

First human implant of the cardiac contractility modulation in patient with dilated cardiomyopathy–related laminopathy
por: D’Onofrio, Antonio, et al.
Publicado: (2023)

Excitation-contraction coupling and cardiac contractile force /
por: Bers, D. M.
Publicado: (1991)

HADP1: new regulator of cardiac contractility
Publicado: (2011)

Ginseng Is Useful to Enhance Cardiac Contractility in Animals
por: Lin, Jia-Wei, et al.
Publicado: (2014)

Cardiac Contractility Modulation: A Technical Review
por: Hesselson, Aaron B.
Publicado: (2022)

Myofilament Alterations Associated with Human R14del-Phospholamban Cardiomyopathy
por: Kumar, Mohit, et al.
Publicado: (2023)

Cardiac Remodeling in the Absence of Cardiac Contractile Dysfunction Is Sufficient to Promote Cancer Progression
por: Awwad, Lama, et al.
Publicado: (2022)

Acute effects of cardiac contractility modulation on human induced pluripotent stem cell–derived cardiomyocytes
por: Feaster, Tromondae K., et al.
Publicado: (2021)

Human in vitro neurocardiac coculture (iv NCC) assay development for evaluating cardiac contractility modulation
por: Narkar, Akshay, et al.
Publicado: (2022)

Comparative Gene Expression Analysis of Mouse and Human Cardiac Maturation
por: Uosaki, Hideki, et al.
Publicado: (2016)

Single-Molecule Localization of the Cardiac Voltage-Gated Sodium Channel Reveals Different Modes of Reorganization at Cardiomyocyte Membrane Domains
por: Vermij, Sarah H., et al.
Publicado: (2020)

The Impact of Cardiac Contractility on Cerebral Blood Flow in Ischemia
por: Wira, Charles R., et al.
Publicado: (2011)

Increased cardiac contractility by decreased HAX-1 expression
por: Zhao, Wen
Publicado: (2012)

Recent advances in understanding cardiac contractility in health and disease
por: MacLeod, Ken T.
Publicado: (2016)

Linking metabolic and contractile dysfunction in aged cardiac myocytes
por: Barton, Gregory P., et al.
Publicado: (2017)

Vezf1 regulates cardiac structure and contractile function
por: Paavola, Jere, et al.
Publicado: (2020)

The Antibiotic Doxycycline Impairs Cardiac Mitochondrial and Contractile Function
por: Wüst, Rob C. I., et al.
Publicado: (2021)

Editorial: Cardiac Microvascular Endothelium Contribution to Cardiac Myocyte Growth, Structure, and Contractile Function
por: Altara, Raffaele, et al.
Publicado: (2019)

Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function
por: Nag, Suman, et al.
Publicado: (2015)

Resistance training and L-arginine supplementation are determinant in genomic stability, cardiac contractility and muscle mass development in rats
por: Stefani, Giuseppe Potrick, et al.
Publicado: (2018)

Contractile force measurement of human induced pluripotent stem cell-derived cardiac cell sheet-tissue
por: Sasaki, Daisuke, et al.
Publicado: (2018)

Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues
por: Ravenscroft, Stephanie M., et al.
Publicado: (2016)

In situ transcriptome characteristics are lost following culture adaptation of adult cardiac stem cells
por: Kim, Taeyong, et al.
Publicado: (2018)

Ablation of cardiac myosin–binding protein-C accelerates contractile kinetics in engineered cardiac tissue
por: de Lange, Willem J., et al.
Publicado: (2013)

Human Embryonic Stem Cell Derived Mesenchymal Progenitors Express Cardiac Markers but Do Not Form Contractile Cardiomyocytes
por: Raynaud, Christophe M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_icn51u838dva4s85b8spp29add