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NCOA2 promotes lytic reactivation of Kaposi’s sarcoma-associated herpesvirus by enhancing the expression of the master switch protein RTA

Reactivation of Kaposi’s sarcoma-associated herpesvirus (KSHV) is important for persistent infection in the host as well as viral oncogenesis. The replication and transcription activator (RTA) encoded by KSHV ORF50 plays a central role in the switch from viral latency to lytic replication. Given tha...

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Detalles Bibliográficos
Autores principales: Wei, Xiaoqin, Bai, Lei, Dong, Lianghui, Liu, Huimei, Xing, Peidong, Zhou, Zhiyao, Wu, Shuwen, Lan, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894885/
https://www.ncbi.nlm.nih.gov/pubmed/31751430
http://dx.doi.org/10.1371/journal.ppat.1008160