β-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers

WNT signaling activation in colorectal cancers (CRCs) occurs through APC inactivation or β-catenin mutations. Both processes promote β-catenin nuclear accumulation, which up-regulates epithelial-to-mesenchymal transition (EMT). We investigated β-catenin localization, transcriptome, and phenotypic di...

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Detalles Bibliográficos
Autores principales: Kim, Won Kyu, Kwon, Yujin, Jang, Mi, Park, Minhee, Kim, Jiyoon, Cho, Suyeon, Jang, Dong Geon, Lee, Wook-Bin, Jung, Sang Hoon, Choi, Hye Jin, Min, Byung Soh, Il Kim, Tae, Hong, Sung Pil, Paik, Young-Ki, Kim, Hoguen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895046/
https://www.ncbi.nlm.nih.gov/pubmed/31804558
http://dx.doi.org/10.1038/s41598-019-54890-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895046/
https://www.ncbi.nlm.nih.gov/pubmed/31804558
http://dx.doi.org/10.1038/s41598-019-54890-9

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