Cargando…

β-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers

WNT signaling activation in colorectal cancers (CRCs) occurs through APC inactivation or β-catenin mutations. Both processes promote β-catenin nuclear accumulation, which up-regulates epithelial-to-mesenchymal transition (EMT). We investigated β-catenin localization, transcriptome, and phenotypic di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Won Kyu, Kwon, Yujin, Jang, Mi, Park, Minhee, Kim, Jiyoon, Cho, Suyeon, Jang, Dong Geon, Lee, Wook-Bin, Jung, Sang Hoon, Choi, Hye Jin, Min, Byung Soh, Il Kim, Tae, Hong, Sung Pil, Paik, Young-Ki, Kim, Hoguen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895046/ https://www.ncbi.nlm.nih.gov/pubmed/31804558 http://dx.doi.org/10.1038/s41598-019-54890-9

Ejemplares similares

Microsatellite instability test using peptide nucleic acid probe-mediated melting point analysis: a comparison study
por: Jang, Mi, et al.
Publicado: (2018)

Prognosis of stage III colorectal carcinomas with FOLFOX adjuvant chemotherapy can be predicted by molecular subtype
por: Kwon, Yujin, et al.
Publicado: (2017)

LEF1, TFE3, and AR are putative diagnostic markers of solid pseudopapillary neoplasms
por: Kim, Eun Kyung, et al.
Publicado: (2017)

Identification of specifically activated angiogenic molecules in HMGB-1-induced angiogenesis
por: Kim, Won Kyu, et al.
Publicado: (2017)

mRNAs containing NMD-competent premature termination codons are stabilized and translated under UPF1 depletion
por: Kim, Won Kyu, et al.
Publicado: (2017)

Survivin is a novel transcription regulator of KIT and is downregulated by miRNA‐494 in gastrointestinal stromal tumors
por: Yun, SeongJu, et al.
Publicado: (2018)

Hypoxia disrupt tight junctions and promote metastasis of oral squamous cell carcinoma via loss of par3
por: Kim, Shihyun, et al.
Publicado: (2023)

Clinicopathologic Features and Molecular Characteristics of Glucose Metabolism Contributing to ¹⁸F-fluorodeoxyglucose Uptake in Gastrointestinal Stromal Tumors
por: Cho, Min-Hee, et al.
Publicado: (2015)

β-catenin induces expression of prohibitin gene in acute leukemic cells
por: Kim, Dong Min, et al.
Publicado: (2017)

Symptom-specific non-pharmacological interventions for behavioural and psychological symptoms of dementia: protocol of an umbrella review of systematic reviews of randomised controlled trials
por: Cho, Eunhee, et al.
Publicado: (2023)

Intestinal Endometriosis Mimicking Carcinoma of Rectum and Sigmoid Colon: A Report of Five Cases
por: Kim, Jin Soo, et al.
Publicado: (2009)

Clinical Impact of Tumor Regression Grade after Preoperative Chemoradiation for Locally Advanced Rectal Cancer: Subset Analyses in Lymph Node Negative Patients
por: Min, Byung Soh, et al.
Publicado: (2011)

Grasp55(−/−) mice display impaired fat absorption and resistance to high-fat diet-induced obesity
por: Kim, Jiyoon, et al.
Publicado: (2020)

The risk of lymph node metastasis makes it unsafe to expand the conventional indications for endoscopic treatment of T1 colorectal cancer: A retrospective study of 428 patients
por: Kim, Bun, et al.
Publicado: (2016)

Identification of novel pathogenic roles of BLZF1/ATF6 in tumorigenesis of gastrointestinal stromal tumor showing Golgi-localized mutant KIT
por: Kwon, Yujin, et al.
Publicado: (2023)

Next-generation sequencing with comprehensive bioinformatics analysis facilitates somatic mosaic APC gene mutation detection in patients with familial adenomatous polyposis
por: Kim, Borahm, et al.
Publicado: (2019)

Improved Imaging of the Cervico-Thoracic Junction in Computed Tomography
por: Cho, Pyong Kon, et al.
Publicado: (2008)

Distribution of Mast Cells and Locations, Depths, and Sizes of the Putative Acupoints CV 8 and KI 16
por: Jung, Sharon Jiyoon, et al.
Publicado: (2017)

Fusobacterium nucleatum induces a tumor microenvironment with diminished adaptive immunity against colorectal cancers
por: Kim, Han Sang, et al.
Publicado: (2023)

Machine Learning Algorithm for Efficient Design of Separated Buffer Super-Junction IGBT
por: Kim, Ki Yeong, et al.
Publicado: (2023)

Effects of a low-FODMAP enteral formula on diarrhea on patients in the intensive care unit
por: Bae, Eunjoo, et al.
Publicado: (2021)

Improvement in Turn-Off Loss of the Super Junction IGBT with Separated n-Buffer Layers
por: Kim, Ki Yeong, et al.
Publicado: (2021)

A systematic study of hexavalent chromium adsorption and removal from aqueous environments using chemically functionalized amorphous and mesoporous silica nanoparticles
por: Jang, Eun-Hye, et al.
Publicado: (2020)

Needle Knife-assisted Endoscopic Polypectomy for a Large Inflammatory Fibroid Colon Polyp by Making Its Stalk into an Omega Shape Using an Endoloop
por: Kim, Byung Chang, et al.
Publicado: (2008)

Selective Laser-Assisted Direct Synthesis of MoS(2) for Graphene/MoS(2) Schottky Junction
por: Jeon, Min Ji, et al.
Publicado: (2023)

Metabolic characteristics of solid pseudopapillary neoplasms of the pancreas: their relationships with high intensity (18)F-FDG PET images
por: Park, Minhee, et al.
Publicado: (2018)

Colchicine may assist in reducing granulation tissue in junctional epidermolysis bullosa
por: Kim, Minhee, et al.
Publicado: (2016)

Observation of a Flowing Duct in the Abdominal Wall by Using Nanoparticles
por: Jang, HyunSuk, et al.
Publicado: (2016)

JIB-04, A Small Molecule Histone Demethylase Inhibitor, Selectively Targets Colorectal Cancer Stem Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway
por: Kim, Min Seong, et al.
Publicado: (2018)

Progesterone Receptor Membrane Component 1 suppresses the p53 and Wnt/β-catenin pathways to promote human pluripotent stem cell self-renewal
por: Kim, Ji Yea, et al.
Publicado: (2018)

Wnt5a attenuates the pathogenic effects of the Wnt/β-catenin pathway in human retinal pigment epithelial cells via down-regulating β-catenin and Snail
por: Kim, Joo-Hyun, et al.
Publicado: (2015)

Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients
por: Kim, Hyun O, et al.
Publicado: (2013)

Ilimaquinone and Ethylsmenoquinone, Marine Sponge Metabolites, Suppress the Proliferation of Multiple Myeloma Cells by Down-Regulating the Level of β-Catenin
por: Park, Seoyoung, et al.
Publicado: (2014)

Signet-ring cell carcinoma of the appendix: a case report with an emphasis on sonographic findings
por: Cho, Young Jong, et al.
Publicado: (2016)

Therapeutic and Tumor-specific Immunity Induced by Combination of Dendritic Cells and Oncolytic Adenovirus Expressing IL-12 and 4-1BBL
por: Huang, Jing-Hua, et al.
Publicado: (2009)

Diagnostic Significance of Serum HMGB1 in Colorectal Carcinomas
por: Lee, Hanna, et al.
Publicado: (2012)

HMP-1/α-catenin promotes junctional mechanical integrity during morphogenesis
por: Vuong-Brender, Thanh Thi Kim, et al.
Publicado: (2018)

Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles (PGA-4HGF) by β-Catenin Activation and Its Related Cell Cycle Molecules
por: Lee, Hye-Ji, et al.
Publicado: (2019)

Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells
por: Jang, Ji-Young, et al.
Publicado: (2012)

Antiseptic Effect of Ps-K18: Mechanism of Its Antibacterial and Anti-Inflammatory Activities
por: Jang, Mihee, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_j2fkoafkkq74gopjbr3km68tu9