Brain targeting of 9c,11t-Conjugated Linoleic Acid, a natural calpain inhibitor, preserves memory and reduces Aβ and P25 accumulation in 5XFAD mice

Deregulation of Cyclin-dependent kinase 5 (CDK5) by binding to the activated calpain product p25, is associated with the onset of neurodegenerative diseases, such as Alzheimer’s disease (AD). Conjugated Linoleic Acid (CLA), a calpain inhibitor, is a metabolite of Punicic Acid (PA), the main componen...

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Detalles Bibliográficos
Autores principales: Binyamin, Orli, Nitzan, Keren, Frid, Kati, Ungar, Yael, Rosenmann, Hanna, Gabizon, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895090/
https://www.ncbi.nlm.nih.gov/pubmed/31804596
http://dx.doi.org/10.1038/s41598-019-54971-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895090/
https://www.ncbi.nlm.nih.gov/pubmed/31804596
http://dx.doi.org/10.1038/s41598-019-54971-9

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