A dual inhibitor of the proteasome catalytic subunits LMP2 and Y attenuates disease progression in mouse models of Alzheimer’s disease

The immunoproteasome (iP) is a variant of the constitutive proteasome (cP) that is abundantly expressed in immune cells which can also be induced in somatic cells by cytokines such as TNF-α or IFN-γ. Accumulating evidence support that the iP is closely linked to multiple facets of inflammatory respo...

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Detalles Bibliográficos
Autores principales: Yeo, In Jun, Lee, Min Jae, Baek, Ahruem, Miller, Zachary, Bhattarai, Deepak, Baek, Yu Mi, Jeong, Hyun Jung, Kim, Yun Kyung, Kim, Dong-Eun, Hong, Jin Tae, Kim, Kyung Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895163/
https://www.ncbi.nlm.nih.gov/pubmed/31804556
http://dx.doi.org/10.1038/s41598-019-54846-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895163/
https://www.ncbi.nlm.nih.gov/pubmed/31804556
http://dx.doi.org/10.1038/s41598-019-54846-z

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