Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

African trypanosomiasis is a disease caused by Trypanosoma brucei parasites with limited treatment options. Trypanosoma is unable to synthesize purines de novo and relies solely on their uptake and interconversion from the host, constituting purine nucleoside analogues a potential source of antitryp...

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Detalles Bibliográficos
Autores principales: Hulpia, Fabian, Mabille, Dorien, Campagnaro, Gustavo D., Schumann, Gabriela, Maes, Louis, Roditi, Isabel, Hofer, Anders, de Koning, Harry P., Caljon, Guy, Van Calenbergh, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895180/
https://www.ncbi.nlm.nih.gov/pubmed/31804484
http://dx.doi.org/10.1038/s41467-019-13522-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895180/
https://www.ncbi.nlm.nih.gov/pubmed/31804484
http://dx.doi.org/10.1038/s41467-019-13522-6

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