LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients

Mutations in LRRK2 and GBA1 are common genetic risk factors for Parkinson’s disease (PD) and major efforts are underway to develop new therapeutics that target LRRK2 or glucocerebrosidase (GCase). Here we describe a mechanistic and therapeutic convergence of LRRK2 and GCase in neurons derived from p...

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Detalles Bibliográficos
Autores principales: Ysselstein, Daniel, Nguyen, Maria, Young, Tiffany J., Severino, Alex, Schwake, Michael, Merchant, Kalpana, Krainc, Dimitri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895201/
https://www.ncbi.nlm.nih.gov/pubmed/31804465
http://dx.doi.org/10.1038/s41467-019-13413-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895201/
https://www.ncbi.nlm.nih.gov/pubmed/31804465
http://dx.doi.org/10.1038/s41467-019-13413-w

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