DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel housekeeper of hepatic mitochondrial homeostasis outside the DNA repair process. In this study, DNA-PKcs was upregulated in the livers of mice that were exposed to alcohol; the expression of DNA-PKcs positively correlated with hepa...

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Detalles Bibliográficos
Autores principales: Zhou, Hao, Zhu, Pingjun, Wang, Jin, Toan, Sam, Ren, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895206/
https://www.ncbi.nlm.nih.gov/pubmed/31839999
http://dx.doi.org/10.1038/s41392-019-0094-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895206/
https://www.ncbi.nlm.nih.gov/pubmed/31839999
http://dx.doi.org/10.1038/s41392-019-0094-1

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