Enhancer-mediated enrichment of interacting JMJD3–DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription

ENPP2, which encodes for the enzyme autotaxin (ATX), is overexpressed during chronic inflammatory diseases and various cancers. However, the molecular mechanism involved in the ENPP2 transcription remains elusive. Here, in HEK 293T cells, we demonstrated that lipopolysaccharide (LPS) increased the t...

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Detalles Bibliográficos
Autores principales: Argaud, Deborah, Boulanger, Marie-Chloé, Chignon, Arnaud, Mkannez, Ghada, Mathieu, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895255/
https://www.ncbi.nlm.nih.gov/pubmed/31251802
http://dx.doi.org/10.1093/nar/gkz560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895255/
https://www.ncbi.nlm.nih.gov/pubmed/31251802
http://dx.doi.org/10.1093/nar/gkz560

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