Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation

DNA mismatches are highly polymorphic and dynamic in nature, albeit poorly characterized structurally. We utilized the antitumour antibiotic Co(II)(Chro)(2) (Chro = chromomycin A3) to stabilize the palindromic duplex d(TTGGCGAA) DNA with two G:G mismatches, allowing X-ray crystallography-based monit...

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Detalles Bibliográficos
Autores principales: Satange, Roshan, Chuang, Chien-Ying, Neidle, Stephen, Hou, Ming-Hon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895262/
https://www.ncbi.nlm.nih.gov/pubmed/31361900
http://dx.doi.org/10.1093/nar/gkz653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895262/
https://www.ncbi.nlm.nih.gov/pubmed/31361900
http://dx.doi.org/10.1093/nar/gkz653

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