Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine

The psychiatric risk-associated transcription factor 4 (TCF4) is linked to schizophrenia. Rare TCF4 coding variants are found in individuals with Pitt-Hopkins syndrome—an intellectual disability and autism spectrum disorder. TCF4 contains a C-terminal basic-helix-loop-helix (bHLH) DNA binding domain...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Jie, Horton, John R, Li, Jia, Huang, Yun, Zhang, Xing, Blumenthal, Robert M, Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895265/
https://www.ncbi.nlm.nih.gov/pubmed/31081034
http://dx.doi.org/10.1093/nar/gkz381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895265/
https://www.ncbi.nlm.nih.gov/pubmed/31081034
http://dx.doi.org/10.1093/nar/gkz381

Ejemplares similares