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Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine

The psychiatric risk-associated transcription factor 4 (TCF4) is linked to schizophrenia. Rare TCF4 coding variants are found in individuals with Pitt-Hopkins syndrome—an intellectual disability and autism spectrum disorder. TCF4 contains a C-terminal basic-helix-loop-helix (bHLH) DNA binding domain...

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Detalles Bibliográficos
Autores principales:	Yang, Jie, Horton, John R, Li, Jia, Huang, Yun, Zhang, Xing, Blumenthal, Robert M, Cheng, Xiaodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895265/ https://www.ncbi.nlm.nih.gov/pubmed/31081034 http://dx.doi.org/10.1093/nar/gkz381

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