Sharp kinking of a coiled-coil in MutS allows DNA binding and release

DNA mismatch repair (MMR) corrects mismatches, small insertions and deletions in DNA during DNA replication. While scanning for mismatches, dimers of MutS embrace the DNA helix with their lever and clamp domains. Previous studies indicated generic flexibility of the lever and clamp domains of MutS p...

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Detalles Bibliográficos
Autores principales: Bhairosing-Kok, Doreth, Groothuizen, Flora S, Fish, Alexander, Dharadhar, Shreya, Winterwerp, Herrie H K, Sixma, Titia K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895276/
https://www.ncbi.nlm.nih.gov/pubmed/31372631
http://dx.doi.org/10.1093/nar/gkz649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895276/
https://www.ncbi.nlm.nih.gov/pubmed/31372631
http://dx.doi.org/10.1093/nar/gkz649

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