CoA‐dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases

PKAN, CoPAN, MePAN, and PDH‐E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus pallidus occurs in these genetic neurodegenerative diseases, which arise from defects in CoA biosynthesis (PKAN, CoPAN), protein lipoylation (MeP...

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Detalles Bibliográficos
Autores principales: Lambrechts, Roald A, Schepers, Hein, Yu, Yi, van der Zwaag, Marianne, Autio, Kaija J, Vieira‐Lara, Marcel A, Bakker, Barbara M, Tijssen, Marina A, Hayflick, Susan J, Grzeschik, Nicola A, Sibon, Ody CM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895606/
https://www.ncbi.nlm.nih.gov/pubmed/31701655
http://dx.doi.org/10.15252/emmm.201910488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895606/
https://www.ncbi.nlm.nih.gov/pubmed/31701655
http://dx.doi.org/10.15252/emmm.201910488

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