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The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma

The mitochondrial deoxynucleotide triphosphate (dNTP) is maintained by the mitochondrial deoxynucleoside salvage pathway and dedicated for the mtDNA homeostasis, and the mitochondrial deoxyguanosine kinase (DGUOK) is a rate‐limiting enzyme in this pathway. Here, we investigated the role of the DGUOK...

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Detalles Bibliográficos
Autores principales: Lin, Shengchen, Huang, Chongbiao, Sun, Jianwei, Bollt, Oana, Wang, Xiuchao, Martine, Eric, Kang, Jiaxin, Taylor, Matthew D, Fang, Bin, Singh, Pankaj K, Koomen, John, Hao, Jihui, Yang, Shengyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895611/
https://www.ncbi.nlm.nih.gov/pubmed/31633874
http://dx.doi.org/10.15252/emmm.201910849