Improved Retinal Organoid Differentiation by Modulating Signaling Pathways Revealed by Comparative Transcriptome Analyses with Development In Vivo

Stem cell-derived retinal organoids recapitulate many landmarks of in vivo differentiation but lack functional maturation of distinct cell types, especially photoreceptors. Using comprehensive temporal transcriptome analyses, we show that transcriptome shift from postnatal day 6 (P6) to P10, associa...

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Detalles Bibliográficos
Autores principales: Brooks, Matthew J., Chen, Holly Y., Kelley, Ryan A., Mondal, Anupam K., Nagashima, Kunio, De Val, Natalia, Li, Tiansen, Chaitankar, Vijender, Swaroop, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895716/
https://www.ncbi.nlm.nih.gov/pubmed/31631019
http://dx.doi.org/10.1016/j.stemcr.2019.09.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895716/
https://www.ncbi.nlm.nih.gov/pubmed/31631019
http://dx.doi.org/10.1016/j.stemcr.2019.09.009

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