WEE1 Inhibition Enhances Anti-Apoptotic Dependency as a Result of Premature Mitotic Entry and DNA Damage

Genomically unstable cancers are dependent on specific cell cycle checkpoints to maintain viability and prevent apoptosis. The cell cycle checkpoint protein WEE1 is highly expressed in genomically unstable cancers, including diffuse large B-cell lymphoma (DLBCL). Although WEE1 inhibition effectively...

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Detalles Bibliográficos
Autores principales: de Jong, Mathilde Rikje Willemijn, Langendonk, Myra, Reitsma, Bart, Herbers, Pien, Nijland, Marcel, Huls, Gerwin, van den Berg, Anke, Ammatuna, Emanuele, Visser, Lydia, van Meerten, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895818/
https://www.ncbi.nlm.nih.gov/pubmed/31703356
http://dx.doi.org/10.3390/cancers11111743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895818/
https://www.ncbi.nlm.nih.gov/pubmed/31703356
http://dx.doi.org/10.3390/cancers11111743

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