The Alpha Isoform of Heat Shock Protein 90 and the Co-chaperones p23 and Cdc37 Promote Opioid Anti-nociception in the Brain

Opioid activation of the mu opioid receptor (MOR) promotes signaling cascades that evoke both analgesic responses to pain and side effects like addiction and dependence. Manipulation of these cascades, such as by biased agonism, has great promise to improve opioid therapy. However, the signaling cas...

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Detalles Bibliográficos
Autores principales: Lei, Wei, Duron, David I., Stine, Carrie, Mishra, Sanket, Blagg, Brian S. J., Streicher, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895903/
https://www.ncbi.nlm.nih.gov/pubmed/31849607
http://dx.doi.org/10.3389/fnmol.2019.00294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895903/
https://www.ncbi.nlm.nih.gov/pubmed/31849607
http://dx.doi.org/10.3389/fnmol.2019.00294

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