Synergism Through WEE1 and CHK1 Inhibition in Acute Lymphoblastic Leukemia

Introduction: Screening for synthetic lethality markers has demonstrated that the inhibition of the cell cycle checkpoint kinases WEE1 together with CHK1 drastically affects stability of the cell cycle and induces cell death in rapidly proliferating cells. Exploiting this finding for a possible ther...

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Detalles Bibliográficos
Autores principales: Ghelli Luserna Di Rorà, Andrea, Bocconcelli, Matteo, Ferrari, Anna, Terragna, Carolina, Bruno, Samantha, Imbrogno, Enrica, Beeharry, Neil, Robustelli, Valentina, Ghetti, Martina, Napolitano, Roberta, Chirumbolo, Gabriella, Marconi, Giovanni, Papayannidis, Cristina, Paolini, Stefania, Sartor, Chiara, Simonetti, Giorgia, Yen, Timothy J., Martinelli, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895917/
https://www.ncbi.nlm.nih.gov/pubmed/31717700
http://dx.doi.org/10.3390/cancers11111654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895917/
https://www.ncbi.nlm.nih.gov/pubmed/31717700
http://dx.doi.org/10.3390/cancers11111654

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