Efficient Gene Disruption via Base Editing Induced Stop in Newt Pleurodeles waltl

Loss-of-function approaches provide strong evidence for determining the role of particular genes. The prevalent CRISPR/Cas9 technique is widely used to disrupt target gene with uncontrolled non-homologous end joining after the double strand breaks, which results in mosaicism and multiple genotypes i...

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Detalles Bibliográficos
Autores principales: Cai, Hao, Peng, Zhelun, Ren, Ruimin, Wang, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895984/
https://www.ncbi.nlm.nih.gov/pubmed/31652881
http://dx.doi.org/10.3390/genes10110837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895984/
https://www.ncbi.nlm.nih.gov/pubmed/31652881
http://dx.doi.org/10.3390/genes10110837

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