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Efficient Gene Disruption via Base Editing Induced Stop in Newt Pleurodeles waltl
Loss-of-function approaches provide strong evidence for determining the role of particular genes. The prevalent CRISPR/Cas9 technique is widely used to disrupt target gene with uncontrolled non-homologous end joining after the double strand breaks, which results in mosaicism and multiple genotypes i...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895984/ https://www.ncbi.nlm.nih.gov/pubmed/31652881 http://dx.doi.org/10.3390/genes10110837 |