Genomic-Destabilization-Associated Mutagenesis and Clonal Evolution of Cells with Mutations in Tumor-Suppressor Genes

The development of cancer is driven by genomic instability and mutations. In general, cancer develops via multiple steps. Each step involves the clonal evolution of cells with abrogated defense systems, such as cells with mutations in cancer-suppressor genes. However, it remains unclear how cellular...

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Detalles Bibliográficos
Autores principales: Yoshioka, Ken-ichi, Matsuno, Yusuke, Hyodo, Mai, Fujimori, Haruka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895985/
https://www.ncbi.nlm.nih.gov/pubmed/31653100
http://dx.doi.org/10.3390/cancers11111643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895985/
https://www.ncbi.nlm.nih.gov/pubmed/31653100
http://dx.doi.org/10.3390/cancers11111643

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