Genomic-Destabilization-Associated Mutagenesis and Clonal Evolution of Cells with Mutations in Tumor-Suppressor Genes

The development of cancer is driven by genomic instability and mutations. In general, cancer develops via multiple steps. Each step involves the clonal evolution of cells with abrogated defense systems, such as cells with mutations in cancer-suppressor genes. However, it remains unclear how cellular...

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Detalles Bibliográficos
Autores principales: Yoshioka, Ken-ichi, Matsuno, Yusuke, Hyodo, Mai, Fujimori, Haruka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895985/
https://www.ncbi.nlm.nih.gov/pubmed/31653100
http://dx.doi.org/10.3390/cancers11111643
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author Yoshioka, Ken-ichi
Matsuno, Yusuke
Hyodo, Mai
Fujimori, Haruka
author_facet Yoshioka, Ken-ichi
Matsuno, Yusuke
Hyodo, Mai
Fujimori, Haruka
author_sort Yoshioka, Ken-ichi
collection PubMed
description The development of cancer is driven by genomic instability and mutations. In general, cancer develops via multiple steps. Each step involves the clonal evolution of cells with abrogated defense systems, such as cells with mutations in cancer-suppressor genes. However, it remains unclear how cellular defense systems are abrogated and the associated clonal evolution is triggered and propagated. In this manuscript, we review current knowledge regarding mutagenesis associated with genomic destabilization and its relationship with the clonal evolution of cells over the course of cancer development, focusing especially on mechanistic aspects.
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spelling pubmed-68959852019-12-24 Genomic-Destabilization-Associated Mutagenesis and Clonal Evolution of Cells with Mutations in Tumor-Suppressor Genes Yoshioka, Ken-ichi Matsuno, Yusuke Hyodo, Mai Fujimori, Haruka Cancers (Basel) Review The development of cancer is driven by genomic instability and mutations. In general, cancer develops via multiple steps. Each step involves the clonal evolution of cells with abrogated defense systems, such as cells with mutations in cancer-suppressor genes. However, it remains unclear how cellular defense systems are abrogated and the associated clonal evolution is triggered and propagated. In this manuscript, we review current knowledge regarding mutagenesis associated with genomic destabilization and its relationship with the clonal evolution of cells over the course of cancer development, focusing especially on mechanistic aspects. MDPI 2019-10-24 /pmc/articles/PMC6895985/ /pubmed/31653100 http://dx.doi.org/10.3390/cancers11111643 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yoshioka, Ken-ichi
Matsuno, Yusuke
Hyodo, Mai
Fujimori, Haruka
Genomic-Destabilization-Associated Mutagenesis and Clonal Evolution of Cells with Mutations in Tumor-Suppressor Genes
title Genomic-Destabilization-Associated Mutagenesis and Clonal Evolution of Cells with Mutations in Tumor-Suppressor Genes
title_full Genomic-Destabilization-Associated Mutagenesis and Clonal Evolution of Cells with Mutations in Tumor-Suppressor Genes
title_fullStr Genomic-Destabilization-Associated Mutagenesis and Clonal Evolution of Cells with Mutations in Tumor-Suppressor Genes
title_full_unstemmed Genomic-Destabilization-Associated Mutagenesis and Clonal Evolution of Cells with Mutations in Tumor-Suppressor Genes
title_short Genomic-Destabilization-Associated Mutagenesis and Clonal Evolution of Cells with Mutations in Tumor-Suppressor Genes
title_sort genomic-destabilization-associated mutagenesis and clonal evolution of cells with mutations in tumor-suppressor genes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895985/
https://www.ncbi.nlm.nih.gov/pubmed/31653100
http://dx.doi.org/10.3390/cancers11111643
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