Cargando…

Antitumor Reactive T-Cell Responses Are Enhanced In Vivo by DAMP Prothymosin Alpha and Its C-Terminal Decapeptide

Prothymosin α (proTα) and its C-terminal decapeptide proTα(100–109) were shown to pleiotropically enhance innate and adaptive immune responses. Their activities have been broadly studied in vitro, focusing primarily on the restoration of the deficient immunoreactivity of cancer patients’ leukocytes....

Descripción completa

Detalles Bibliográficos
Autores principales:	Birmpilis, Anastasios I., Karachaliou, Chrysoula-Evangelia, Samara, Pinelopi, Ioannou, Kyriaki, Selemenakis, Platon, Kostopoulos, Ioannis V., Kavrochorianou, Nadia, Kalbacher, Hubert, Livaniou, Evangelia, Haralambous, Sylva, Kotsinas, Athanasios, Farzaneh, Farzin, Trougakos, Ioannis P., Voelter, Wolfgang, Dimopoulos, Meletios-Athanasios, Bamias, Aristotelis, Tsitsilonis, Ourania
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896021/ https://www.ncbi.nlm.nih.gov/pubmed/31717548 http://dx.doi.org/10.3390/cancers11111764

Ejemplares similares

Development of a specific IgY-based ELISA for prothymosin alpha, a bioactive polypeptide with diagnostic and therapeutic potential()
por: Karachaliou, Chrysoula-Evangelia, et al.
Publicado: (2019)

Prothymosin α and a prothymosin α-derived peptide enhance T(H)1-type immune responses against defined HER-2/neu epitopes
por: Ioannou, Kyriaki, et al.
Publicado: (2013)

Immunogenic Cell Death, DAMPs and Prothymosin α as a Putative Anticancer Immune Response Biomarker
por: Birmpilis, Anastasios I., et al.
Publicado: (2022)

A fragment of the alarmin prothymosin α as a novel biomarker in murine models of bacteria-induced sepsis
por: Samara, Pinelopi, et al.
Publicado: (2017)

Immunosensors for Autoimmune-Disease-Related Biomarkers: A Literature Review
por: Karachaliou, Chrysoula-Evangelia, et al.
Publicado: (2023)

IgY technology: Methods for developing and evaluating avian immunoglobulins for the in vitro detection of biomolecules
por: Karachaliou, Chrysoula-Evangelia, et al.
Publicado: (2021)

Fast and Sensitive Determination of the Fungicide Carbendazim in Fruit Juices with an Immunosensor Based on White Light Reflectance Spectroscopy †
por: Koukouvinos, Georgios, et al.
Publicado: (2021)

Clusterin overexpression in mice exacerbates diabetic phenotypes but suppresses tumor progression in a mouse melanoma model
por: Cheimonidi, Christina, et al.
Publicado: (2021)

Recent Developments in the Field of Optical Immunosensors Focusing on a Label-Free, White Light Reflectance Spectroscopy-Based Immunosensing Platform
por: Karachaliou, Chrysoula-Evangelia, et al.
Publicado: (2022)

Cortisol Immunosensors: A Literature Review
por: Karachaliou, Chrysoula-Evangelia, et al.
Publicado: (2023)

Peptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives
por: Vassilakopoulou, Vyronia, et al.
Publicado: (2021)

Fast and Accurate Determination of Minute Ochratoxin A Levels in Cereal Flours and Wine with the Label-Free White Light Reflectance Spectroscopy Biosensing Platform †
por: Karachaliou, Chrysoula-Evangelia, et al.
Publicado: (2022)

Prothymosin Alpha and Immune Responses: Are We Close to Potential Clinical Applications?
por: Samara, P., et al.
Publicado: (2016)

Recovery of Innate Immune Cells and Persisting Alterations in Adaptive Immunity in the Peripheral Blood of Convalescent Plasma Donors at Eight Months Post SARS-CoV-2 Infection
por: Kostopoulos, Ioannis V., et al.
Publicado: (2021)

Serological testing for SARS-CoV-2: Advancements and future challenges
por: Alexopoulos, Harry, et al.
Publicado: (2023)

Clinical usefulness of testing for severe acute respiratory syndrome coronavirus 2 antibodies
por: Alexopoulos, Harry, et al.
Publicado: (2023)

The Cytogenetic Profile of Primary and Secondary Plasma Cell Leukemia: Etiopathogenetic Perspectives, Prognostic Impact and Clinical Relevance to Newly Diagnosed Multiple Myeloma with Differential Circulating Clonal Plasma Cells
por: Papadhimitriou, Stefanos I., et al.
Publicado: (2022)

Distinct type I interferon responses between younger women and older men contribute to the variability of COVID-19 outcomes: Hypothesis generating insights from COVID-19 convalescent individuals
por: Mavragani, Clio P., et al.
Publicado: (2022)

Peripheral Blood Immune Profiling of Convalescent Plasma Donors Reveals Alterations in Specific Immune Subpopulations Even at 2 Months Post SARS-CoV-2 Infection
por: Orologas-Stavrou, Nikolaos, et al.
Publicado: (2020)

Evaluation of minimal residual disease using next-generation flow cytometry in patients with AL amyloidosis
por: Kastritis, Efstathios, et al.
Publicado: (2018)

Prothymosin α overexpression contributes to the development of pulmonary emphysema
por: Su, Bing-Hua, et al.
Publicado: (2013)

Molecular responses to therapeutic proteasome inhibitors in multiple myeloma patients are donor-, cell type- and drug-dependent
por: Papanagnou, Eleni-Dimitra, et al.
Publicado: (2018)

Profile of trebananib (AMG386) and its potential in the treatment of ovarian cancer
por: Liontos, Michalis, et al.
Publicado: (2014)

Seroprevalence of Antibodies against SARS-CoV-2 among the Personnel and Students of the National and Kapodistrian University of Athens, Greece: A Preliminary Report
por: Tsitsilonis, Ourania E., et al.
Publicado: (2020)

Ex Vivo Models Simulating the Bone Marrow Environment and Predicting Response to Therapy in Multiple Myeloma
por: Papadimitriou, Konstantinos, et al.
Publicado: (2020)

Development and immunochemical evaluation of a novel chicken IgY antibody specific for KLK6
por: Sotiropoulou, Georgia, et al.
Publicado: (2012)

Minimal Residual Disease in Multiple Myeloma: Current Landscape and Future Applications With Immunotherapeutic Approaches
por: Kostopoulos, Ioannis V., et al.
Publicado: (2020)

Novel Decapeptides that Bind Avidly and Deliver Radioisotope to Colon Cancer Cells
por: Abraham, John M., et al.
Publicado: (2007)

Novel Activity of a Synthetic Decapeptide Against Toxoplasma gondii Tachyzoites
por: Giovati, Laura, et al.
Publicado: (2018)

Tryptophan-Containing Cyclic Decapeptides with Activity against Plant Pathogenic Bacteria
por: Camó, Cristina, et al.
Publicado: (2017)

Overexpression of prothymosin-α in glioma is associated with tumor aggressiveness and poor prognosis
por: Kumar, Anurag, et al.
Publicado: (2022)

The Safety and Effectiveness of Decapeptide in Patients With Vitiligo: A Real-World Study
por: Sharma, Aseem, et al.
Publicado: (2023)

SARS-CoV-2 Infection Is Asymptomatic in Nearly Half of Adults with Robust Anti-Spike Protein Receptor-Binding Domain Antibody Response
por: Tsitsilonis, Ourania E., et al.
Publicado: (2021)

Non-Traditional Cardiovascular Risk Factors in Adolescents with Obesity and Metabolic Syndrome May Predict Future Cardiovascular Disease
por: Tragomalou, Athanasia, et al.
Publicado: (2023)

Cardiovascular Toxicity of Proteasome Inhibitors: Underlying Mechanisms and Management Strategies: JACC: CardioOncology State-of-the-Art Review
por: Georgiopoulos, Georgios, et al.
Publicado: (2023)

Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications
por: Trougakos, Ioannis P., et al.
Publicado: (2021)

Impact of Minimal Residual Disease Detection by Next-Generation Flow Cytometry in Multiple Myeloma Patients with Sustained Complete Remission after Frontline Therapy
por: Terpos, Evangelos, et al.
Publicado: (2019)

Effect of CPAP treatment on endothelial function and plasma CRP levels in patients with sleep apnea
por: Panoutsopoulos, Athanasios, et al.
Publicado: (2012)

Deep Phenotyping Reveals Distinct Immune Signatures Correlating with Prognostication, Treatment Responses, and MRD Status in Multiple Myeloma
por: Papadimitriou, Konstantinos, et al.
Publicado: (2020)

Overexpression of hepatic prothymosin alpha, a novel marker for human hepatocellular carcinoma.
por: Wu, C. G., et al.
Publicado: (1997)

Cannot write session to /tmp/vufind_sessions/sess_v1qm9q3bf4d6e38p1b00ochikr