Rationale for a Combination Therapy Consisting of MCL1- and MEK-Inhibitors in Acute Myeloid Leukemia

Amplification and overexpression of the myeloid cell leukemia differentiation protein MCL1 and the murine double minute protein MDM2 have been reported in various human tumors as well as hematological malignancies including acute myeloid leukemia (AML). While MCL1 is an anti-apoptotic member of the...

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Detalles Bibliográficos
Autores principales: Seipel, Katja, Schmitter, Karin, Bacher, Ulrike, Pabst, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896073/
https://www.ncbi.nlm.nih.gov/pubmed/31718075
http://dx.doi.org/10.3390/cancers11111779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896073/
https://www.ncbi.nlm.nih.gov/pubmed/31718075
http://dx.doi.org/10.3390/cancers11111779

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