Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1

Janus kinases (JAKs) are found constitutively associated with cytokine receptors and are present in an inactive state prior to cytokine exposure. Activating mutations of JAKs are causative for a number of leukemias, lymphomas, and myeloproliferative diseases. In particular, the JAK2(V617F) mutant is...

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Detalles Bibliográficos
Autores principales: Liau, Nicholas P. D., Laktyushin, Artem, Morris, Rhiannon, Sandow, Jarrod J., Nicola, Nicos A., Kershaw, Nadia J., Babon, Jeffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896158/
https://www.ncbi.nlm.nih.gov/pubmed/31683831
http://dx.doi.org/10.3390/cancers11111701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896158/
https://www.ncbi.nlm.nih.gov/pubmed/31683831
http://dx.doi.org/10.3390/cancers11111701

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