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Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1
Janus kinases (JAKs) are found constitutively associated with cytokine receptors and are present in an inactive state prior to cytokine exposure. Activating mutations of JAKs are causative for a number of leukemias, lymphomas, and myeloproliferative diseases. In particular, the JAK2(V617F) mutant is...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896158/ https://www.ncbi.nlm.nih.gov/pubmed/31683831 http://dx.doi.org/10.3390/cancers11111701 |