Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors

In this study, newly synthesised compounds 6, 8, 10 and other compounds (1–5, 7 and 9) and their inhibitory properties against the human isoforms hCA I and hCA II were reported for the first time. Compounds 1–10 showed effective inhibition profiles with K(I) values in the range of 5.13–16.9 nM for h...

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Detalles Bibliográficos
Autores principales: Dizdaroglu, Yazgı, Albay, Canan, Arslan, Tayfun, Ece, Abdulilah, Turkoglu, Emir A., Efe, Asiye, Senturk, Murat, Supuran, Claudiu T., Ekinci, Deniz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896446/
https://www.ncbi.nlm.nih.gov/pubmed/31797703
http://dx.doi.org/10.1080/14756366.2019.1695791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896446/
https://www.ncbi.nlm.nih.gov/pubmed/31797703
http://dx.doi.org/10.1080/14756366.2019.1695791

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