Persistent epigenetic memory impedes rescue of the telomeric phenotype in human ICF iPSCs following DNMT3B correction

DNA methyltransferase 3B (DNMT3B) is the major DNMT that methylates mammalian genomes during early development. Mutations in human DNMT3B disrupt genome-wide DNA methylation patterns and result in ICF syndrome type 1 (ICF1). To study whether normal DNA methylation patterns may be restored in ICF1 ce...

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Detalles Bibliográficos
Autores principales: Toubiana, Shir, Gagliardi, Miriam, Papa, Mariarosaria, Manco, Roberta, Tzukerman, Maty, Matarazzo, Maria R, Selig, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897513/
https://www.ncbi.nlm.nih.gov/pubmed/31738163
http://dx.doi.org/10.7554/eLife.47859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897513/
https://www.ncbi.nlm.nih.gov/pubmed/31738163
http://dx.doi.org/10.7554/eLife.47859

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