Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

Increased glucose uptake and metabolism is a prominent phenotype of most cancers, but efforts to clinically target this metabolic alteration have been challenging. Here, we present evidence that lactoylglutathione (LGSH), a byproduct of methylglyoxal detoxification, is elevated in both human and mur...

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Detalles Bibliográficos
Autores principales: Luengo, Alba, Abbott, Keene L., Davidson, Shawn M., Hosios, Aaron M., Faubert, Brandon, Chan, Sze Ham, Freinkman, Elizaveta, Zacharias, Lauren G., Mathews, Thomas P., Clish, Clary B., DeBerardinis, Ralph J., Lewis, Caroline A., Vander Heiden, Matthew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898239/
https://www.ncbi.nlm.nih.gov/pubmed/31811141
http://dx.doi.org/10.1038/s41467-019-13419-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898239/
https://www.ncbi.nlm.nih.gov/pubmed/31811141
http://dx.doi.org/10.1038/s41467-019-13419-4

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