The most common RNF43 mutant G659Vfs*41 is fully functional in inhibiting Wnt signaling and unlikely to play a role in tumorigenesis

RNF43 is an E3 ligase that inhibits Wnt signaling by ubiquitinating Wnt receptors for degradation. It is mutated in various cancer types with the most recurrent mutation being the frameshift G659Vfs*41 with frequencies of ~5–8% in colon, stomach and endometrial cancers. This mutation, a deletion of...

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Detalles Bibliográficos
Autores principales: Tu, Jianghua, Park, Soohyun, Yu, Wangsheng, Zhang, Sheng, Wu, Ling, Carmon, Kendra, Liu, Qingyun J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898356/
https://www.ncbi.nlm.nih.gov/pubmed/31811196
http://dx.doi.org/10.1038/s41598-019-54931-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898356/
https://www.ncbi.nlm.nih.gov/pubmed/31811196
http://dx.doi.org/10.1038/s41598-019-54931-3

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