Podocyte hypertrophic stress and detachment precedes hyperglycemia or albuminuria in a rat model of obesity and type2 diabetes-associated nephropathy

Type2 diabetes-associated nephropathy is the commonest cause of renal failure. Mechanisms responsible are controversial. Leptin-deficient hyperphagic Zucker (fa/fa) rats were modeled to test the hypothesis that glomerular enlargement drives podocyte hypertrophic stress leading to accelerated podocyt...

Descripción completa

Detalles Bibliográficos
Autores principales: Minakawa, Akihiro, Fukuda, Akihiro, Sato, Yuji, Kikuchi, Masao, Kitamura, Kazuo, Wiggins, Roger C., Fujimoto, Shouichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898392/
https://www.ncbi.nlm.nih.gov/pubmed/31811176
http://dx.doi.org/10.1038/s41598-019-54692-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898392/
https://www.ncbi.nlm.nih.gov/pubmed/31811176
http://dx.doi.org/10.1038/s41598-019-54692-z

Ejemplares similares